Leg Pain Causes: What May Cause Leg Pain? 16 Conditions That Can Cause Leg Pain

  1. Infections

Infections

Infections can be a less common but significant cause of leg pain. Leg pain due to infections may result from bacteria, viruses, fungi, or parasites. Here’s a more detailed explanation of how infections can lead to leg pain:

  • Cellulitis is a soft tissue (skin) infection caused by a bacterium. It can occur anywhere on the body, including the legs. It often develops when bacteria, usually streptococcus or staphylococcus, enter the skin through a cut, scratch, or other breaks in the skin’s protective barrier.
  • An abscess can be superficial (involving the skin) or deep (involving the muscles and soft tissues). It is a collection of pus (dead cells + pathogens) that results from infection. Abscesses can develop within the soft tissues of the legs, often due to bacteria entering through a wound or hair follicle.
  • Fungal infections, such as athlete’s foot (tinea pedis) or fungal cellulitis, can affect the skin on the legs and cause itching, burning, and pain.
  • Certain systemic infections, such as viral or bacterial infections, can cause generalized symptoms, including muscle and joint pain, which may affect the legs.
  • Some STIs, such as syphilis or herpes, can lead to skin rashes, ulcers, or sores on the genital area, including the legs, and may be associated with pain or discomfort.