Leg Pain Causes: What May Cause Leg Pain? 16 Conditions That Can Cause Leg Pain

4. Peripheral Artery Disease (PAD)

PAD is a circulatory condition where arteries in one or both legs become hardened, narrowed, or blocked. This may cause reduced blood flow to the muscles. Symptoms include pain in the legs and cramping or fatigue during physical activity (claudication). Management includes lifestyle changes, medication, and sometimes surgical procedures to improve blood flow.