Leg Pain Causes: What May Cause Leg Pain? 16 Conditions That Can Cause Leg Pain

16. Tumors

Tumors in or near the leg can cause pain by pressing on nerves, blood vessels, or bones. These tumors can be benign or malignant. Symptoms vary but may include constant or intermittent pain, swelling, weakness, or skin changes. Treatment depends on the tumor type and stage, often involving surgery, radiation, chemotherapy, or a combination.