Bone pain
This type of pain is not caused by having a tumor in the urinary bladder. Instead, it is caused by the spread of bladder cancer into other tissues, and that includes bone tissue. This symptom is found in advanced cases of bladder cancer, and it is highly suspicious of metastasis.
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Most of the symptoms explained above are also seen in benign conditions, such as urinary tract infections, kidney diseases, uterus, and prostate-related problems. The cause of such symptoms can only be confirmed via investigations and various tests performed using samples of blood, urine and through radiological images such as ultrasound and MRI. The workup and some of the criteria to rule out bladder cancers include microscopic analysis of the urine, urine culture and testing for urinary tumor markers, ultrasound KUB, CT scan of the urinary bladder and cystoscopy (a test that is performed to take a biopsy of the bladder cancer to investigate its type). Blood tests such as renal function tests, liver function tests and complete blood count can be done to confirm bladder cancer, as well.