This symptom tends to overlap with the classic right upper quadrant pain of gallstone disease; but it is more diffuse and persistent. Patients describe it as an aching, dragging feeling, especially on the right side. As cancer blocks the bile duct, patients will have a sharper pain.
It is possible to find some relief with different painkillers, like paracetamol. These type of drugs can be useful for rather mild pain. But as the disease advances taking a mild sedative might not be enough. So stronger painkillers can be prescribed, such as codeine or dihydrocodeine (DF118), along with an anti-inflammatory drug (ibuprofen or diclofenac). Keep in mind that your doctor is the one who should make changes to your medication, and you might need more than just over-the-counter drugs. Thus, ask your doctor before starting any type of new medication.