6.Skin disorders
80% of children with Down’s syndrome have at least one type of skin disorder. They could be dark body marks (localized hyperkeratotic lesions), dry skin (xerosis), folliculitis when they reach adolescence, recurrent infections, and sometimes alopecia. In some cases, their skin disorders are associated with other problems, mostly hormonal and autoimmune issues. That’s why patients may also develop vitiligo and other immune-related skin disorders.