9.Endocrine abnormalities
One of the most common endocrine problems is hypothyroidism. 50% of Down syndrome adults have hypothyroidism, and they develop this condition as they grow up, usually through conditions such as Hashimoto thyroiditis. In only a few cases, Hashimoto thyroiditis causes hyperthyroidism instead of hypothyroidism. Another common endocrine disorder is type 1 diabetes, which is found at a higher rate than the rest of the population. 50% of females and most males are infertile.