Medications
There are several medications to improve sciatica pain. Some of them are over-the-counter drugs, such as nonsteroidal anti-inflammatory drugs. Two examples are naproxen and ibuprofen. They improve pain by reducing inflammation and its effects on the sciatic nerve.
Other medications are prescription drugs such as tricyclic antidepressants, anticonvulsant medications, and steroids. Antidepressant and anticonvulsant therapy, in this case, are not prescribed because you have depression or seizure attacks. What they do in sciatica pain is reduce the intensity of the nerve impulses and inhibit certain impulses in the brain. Oral steroids are very potent anti-inflammatory drugs that work better when over-the-counter anti-inflammatories are not enough.