15. Bone pain
One of the most common organs of metastasis in prostate cancer is the bone tissue. So, patients with advanced disease can experience bone pain due to metastasis. This is actually the first sign of prostate cancer metastasis to the bone. It happens because the metastasis areas change the bone structure and cause significant inflammation in the bone tissue. Unlike what people may think, the bones have many blood vessels and nerves, and this causes a dull or sharp ache in the affected area. In some cases, bone pain is not localized but spreads throughout the body.