Breathing problems
They are particularly common in women with advanced disease when cancer has spread to the lungs or is starting to compromise breathing.
Bone pain and other metastasis symptoms
Metastasis symptoms depend on the site of spread. The bones are commonly affected, causing bone pain and hypercalcemia. The patient may also have metastasis in the liver, causing abdominal distention and jaundice. Altered cognitive function and neurologic signs will be found in patients with a distant spread to the brain tissue.