1. Skin hypersensitivity
In most cases, the first manifestations of the disease include a prodromal syndrome characterized by sensitivity changes in the skin. Patients typically feel pain in a specific area that corresponds to the reach of a single nerve. These regions are uniform and depend on body anatomy. Therefore, they can be detected by a skilled physician as dermatomes. Hypersensitivity in dermatomes can be reported as pain or itching. It is one of the first manifestations of the disease and lasts around 48 hours.