5. Loss of Appetite and Weight Loss
GPA is characterized by widespread inflammation in the body, as the immune cells mistakenly attack healthy tissues and blood vessels. This chronic inflammation can lead to a general feeling of illness and malaise, reducing appetite. The disease can affect various organs, including the respiratory tract, kidneys, and skin, as well as others. Depending on the extent of organ involvement, individuals may experience specific symptoms related to those organs, such as coughing, blood in the urine, or skin rashes, which can further contribute to loss of appetite and weight loss.
Many individuals with GPA require treatment with immunosuppressive medications, such as corticosteroids and other immune-modulating drugs. These medications can have side effects, including reduced appetite and weight loss.