2-Brittle nails
In long-standing cases of iron deficiency and vitamin B12 deficiency, patients usually develop brittle and fragile nails. Both deficiencies are associated and coexist with anemia because iron is an essential part of the structure of hemoglobin and vitamin B12 is needed to produce new red blood cells. Therefore, patients with chronic anemia (low levels of hemoglobin in the blood for a very long time) are likely to develop brittle nails, especially when the condition is caused by nutritional problems.