The liver is important for the metabolism of carbohydrates and energy, and it is also an important step to clear out the blood from toxins. When there’s an abnormal function in the liver, the production of energy would also suffer, and patients often feel lightheaded with muscle weakness and tired. As the disease progresses, general malaise becomes chronic fatigue and patients struggle to perform their daily chores and even apparently simple tasks make them feel exhausted.
Fatigue problems become worse in the late-stage of the disease when patients start having neurological manifestations of liver cirrhosis. In these cases, there’s a severe liquid imbalance affecting the brain and may add up to the chronic fatigue.