Skin itching
Jaundice is often associated with itchy skin because, as it builds up, bilirubin stimulates nerve terminals and creates this sensation throughout the body. It is not only bilirubin, but other toxins may start to accumulate and create irritation to the nerve terminals. Sometimes, pruritus in liver cirrhosis tends to be more severe in hands and feet, and it is often difficult to control, even after starting therapy.